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Dangerous Drugs/Product Recalls

11/13/2009
John Cooper
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Neurontin's Effectiveness Apparently Overstated by Pfizer

"There is good evidence of selective outcome reporting in published reports of randomized trials."

So begins the abstract of a special report in the Nov. 12 New England Journal of Medicine. In the report, clinical trial and health policy experts examine original company documents and journal articles related to non-U.S. Food and Drug Administration-approved uses of the Pfizer epilepsy drug Neurontin. The report authors found that the company funded 21 studies of off-label Neurontin use for the prevention of migraine, treatment of bipolar disorder, and treatment of nerve pain and pain resulting from injury or illness. In the 12 off-label studies reported in peer-reviewed medical journals, eight had their primary endpoints--the most-important health outcome, such as a significant reduction in pain severity--changed from the time a study was planned and when a study's findings appeared in print.

As the NEJM article authors concluded, "This practice threatens the validity of evidence for the effectiveness of off-label interventions."

Once the FDA has approved a medication for one use, doctors can prescribe the medication for any purpose. While drugmakers cannot actively market off-label uses for their products, the medical literature is full of studies that report the success of new, unapproved drug uses. When doctors and pharmacists cannot trust in the truthfulness of such journal articles, the health care providers cannot fully protect and appropriately treat their patients.

Because all drugs have side effects, no medications should be used unless conclusive proof exists that the benefits of a medication outweigh its risk. When drugmakers fudge effectiveness data and promote unapproved drug uses, the companies intentionally put patients' health in jeopardy.


About the Editors: Shapiro, Cooper Lewis & Appleton is a law firm which focuses on injury and accident law and we have experience handling dangerous drugs and prescription drug errors. Check out our dangerous drug information page to learn more about side effects and recalls. Our primary office in based in Virginia Beach, Virginia (VA) and we have another office in Elizabeth City, North Carolina (NC). Our lawyers hold licenses in NC, SC, WV, KY and DC. We are ready to talk to you by phone right now—we provide free initial confidential injury case consultations, so call us toll free at 1-800-752-0042. Our injury attorneys also host an extensive injury law video library on Youtube . Furthermore, our lawyers proudly edit the Virginia Beach Injuryboard and Norfolk Injuryboard as a pro bono public information service.



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How should you locate the best, top injury lawyer for your case?

Our Injury Lawyers Have Been Selected For Many Achievements Outlined Below:


Several  Injury Attorneys With Our Firm have been included among the "Best Lawyers in America" 2010 Edition (Lewis-Injury Law, Shapiro-Railroad Injury Law) and been Named As Virginia "Super Lawyers" For Personal Injury Law  (Lewis, Shapiro - 2009 Ed.)(Less than 5% of Outstanding Lawyers are Chosen); also selected by the National Million Dollar Advocates Forum (Lewis, Shapiro - 2009); named among the Top 100 Lawyers in Virginia by ATLA (Shapiro - 2009), and our law firm was the first Injury Law Firm in Virginia Invited to Join Primerus, a select group of Highly Ethical, Respected Law Firms .

In October, 2000 our law firm and co-counsel obtained, what was then, the
largest record verdict in Virginia's history for an injured person (46 Million Dollar Verdict, with Interest, 60 Million Dollars, Settled confidentially during appeal).  Click on icons for more details.

 

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Geographical Areas:

Our personal injury lawyers handle personal injury cases throughout the eastern USA, and work closely with lawyers in other states on signficant injury cases.

As to Virginia (VA), this includes: Norfolk, Virginia Beach, Chesapeake, Portsmouth, Hampton, Newport News, Suffolk, Richmond (entire area), Petersburg, Roanoke/Salem, Alexandria, Arlington, Fairfax, Fredericksburg, Charlottesville, all areas of the Eastern Shore, including Accomack, Onancock, Chincoteauge, Wachapreague, and Cape Charles, Bloxom, Eastville, Exmore, Greenbackville, Machipongo, Mappsville, Melfa, Nassawadox, Onley, Tangier, Temperanceville, Wachapreague, and Wallops Island, Ashland, Big Stone Gap and any other city/ounty.

As to West Virginia (WV) personal injury claims: Bluefield, Beckley, Bridgeport, Charles Town, Charleston, Fairmont, Huntington, Lewisburg, Madison, Martinsburg, Morgantown, Moundsville, Parkersburg, Ripley, Sutton, Weirton, Wheeling, and any other town or county.

Injury Lawyers licensed in VA, WV, NC, SC, KY, FL & Wash., DC.

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